Cerebral Circulation and Metabolism in Uremia

Cerebral circulation and metabolism in uremia.

Data on 16 patients with uremia are presented. The cerebral blood flow was moderately decreased in patients with generalized vascular disease, but was normal in patients with minimal vascular involvement. In both groups the cerebral oxygen consumption (cerebral metabolic rate in terms of oxygen consumption, CAIRO,) was reduced significantly and to the same degree. In contrast, total body metabo...

Effects of aging on cerebral circulation and metabolism.

Newer aspects of carnitine metabolism in uremia.

New knowledge on the physiologic role of L-carnitine and on the rationale of its use in patients on maintenance hemodialysis is provided. In particular, carnitine normalizes plasma and muscle carnitine levels and modifies both enzymatic pattern of muscle and morphology of single fibers, improving exercise tolerance. In addition, carnitine reduces erythropoietin requirements, the number of hypot...

Thalamonal and Cerebral Circulation

Sir,—We read with much interest the fin-: study by Drs Sari, Okuda and Takeshita (Brit. J. Anaesth. (1972) 44, 330) as it relates closely to our own work. As they state, Fitch and his colleagues (1969) reported that fentanyl and droperidol in combination cause a small reduction in intracranial pressure, suggesting that this might be due to a fall in c.b.f. and CMRo,. This led us to study the af...

The Rôle of Renal Metabolism in Hypertension and Uremia

1. The chemical mediator of renal hypertension is rapidly destroyed by the metabolic activity of the normal kidney. The excretory function of the kidney plays little, if any, rôle in eliminating the mediator of hypertension. 2. If specific substances are responsible for the uremic syndrome, they are neither produced nor eliminated to any significant extent by the metabolic activity of the kidne...